This study aims at evaluating the impact of the area of living on cardiometabolic risk and successful aging on older adults (>65 years of age). Characteristics of inhabitants of continental regions i.e. Mani, Greece are compared to those who live in insular Mediterranean areas (i.e., Aegean islands, Crete, Ionian islands, Cyprus, Malta, Sardinia, Corsica), The present work revealed that Mani residents, unlike Mediterranean islanders, are of better health regarding cardiometabolic risk factors. However, islander participants showed better quality of life, as this was expressed by their higher rates in successful aging index, after accounting for age, sex, body mass index (BMI), physical activity, smoking habits, MedDietScore and access to health care services.