The objective of this study is to assess the interaction between comorbidities and self-reported health status as the basis for preventive intervention in care if the elderly. A cross-sectional study was conducted with elderly people (n=120, >65 years) registered in the home health care program “Help at Home”. The ηealth status of the participants was assessed using the Greek version of the screening instrument “HealthOmeter”. This instrument consists of 115 items organized in 8 health domains: social health, mental health, physical health, life habits, medicines, health and care attitudes and utilization, family health and biochemical values. There was high prevalence of chronic comorbidities reported, including mental disorders (6.6%), diabetes melitus (40.8%), hypertension (45.8%) and cardiovascular diseases (33.3%). The overall health status of the participants was reported as “fairly good”. Males scored higher than females on the scales of social health and family health. The overall health status was negatively associated with the presence of diagnosed chronic disease, mental disorders, respiratory symptoms and sensory impairment, even after adjusting for gender, age and smoking. These findings suggest that healthcare professionals should perform a general assessment of the needs of the elderly prior to designing their plan of care.